Table 5.
Inhibition of chemotaxis by Fc constructs. IC50 values. Data are presented as mean of at least two experiments ± SD. n.d., not determined
| Chemokine | Cell line | EC80 (nm) | IC50 Evasin-4 (nm) | IC50 Evasin-4–Fc (nm) | IC50 Fc–Evasin-4 (nm) |
|---|---|---|---|---|---|
| CCL5 | L1.2 CCR5 | 1 | 4.8 ± 1.5 | 9.6 ± 5.1 | n.d. |
| CCL8 | L1.2 CCR2 | 5 | 3.6 ± 2.4 | 6.0 ± 4.1 | 6.4 ± 3.2 |
| CCL11 | L1.2 CCR3 | 1 | 14.0 ± 4.2 | 1539 ± 332 | 88 ± 8 |
| CCL13 | L1.2 CCR2 | 10 | 167 ± 70 | 83 ± 23 | 213 ± 172 |
| CCL22 | L1.2 CCR4 | 1 | 39 ± 18 | 38 ± 7 | n.d. |
| CCL24 | L1.2 CCR3 | 10 | 95 ± 31 | 642 ± 431 | 113 ± 23 |