Fig. 2.

Comparison of gentamicin (GM)-induced cytotoxicity between the auditory (HEI-OC1) cell line and vestibular primary cell culture. (A) GM-induced cytotoxicity in the auditory cell line. Cell viability was 45.5% at the GM concentration of 4 mM for 48 hours. (B) GM-induced cytotoxicity in the primary cell culture. Cell viability was 57.3% at the GM concentration of 2.5 mM for 48 hours. (C) Ratio of relative viability between the auditory cell line and primary cell culture. The higher the concentration of GM was applied to cell cultures, the more cells were damaged. A trend line showed a steady ratio between the auditory cell line and primary cell culture, and vestibular cells were more sensitive to GM-induced cytotoxicity. Results from 5 separate experiments in triplicate.