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Mucin 2 (MUC2)-knockdown tumor growth was retarded with interleukin-6 (IL-6) neutralizing antibody treatment. (A) The macroscopic appearance of the tumor masses after the orthotopic injection of MUC2 RNAi-1 cell clones in mice injected every 3 days with 100 μg of either the IgG1 control antibody (RNAi-1-C) or the IL-6 neutralizing antibody (RNAi-1/IL-6-N). The mice were sacrificed (B) 11 days or (C) 14 days after the tumor cell implantation and tumor weight was determined.
