Table 2.
Proteins identified as significantly associated with structural brain MRI measures in the (A) MCI group and (B) AD group
| (A) MCI group | ||||
|---|---|---|---|---|
| MRI brain region | Protein | Correlation coefficient∗ | Significance (two-tailed) | df |
| Ventricular volume | Clusterin | 0.23 | 0.01 | 115 |
| RANTES | −0.19 | 0.03 | 116 | |
| Mean hippocampal volume | Clusterin | −0.38 | 0.00 | 115 |
| NSE | 0.22 | 0.02 | 116 | |
| Right Entorhinal thickness | Clusterin | −0.22 | 0.02 | 115 |
| Left Entorhinal thickness | Prealbumin | −0.20 | 0.04 | 109 |
| Mean Entorhinal volume | n/a | n/a | n/a | n/a |
| Mean Entorhinal Thickness | n/a | n/a | n/a | n/a |
| Whole Brain Volume | Clusterin | −0.25 | 0.01 | 118 |
| NSE | 0.21 | 0.02 | 119 | |
| RANTES | 0.19 | 0.04 | 119 | |
| (B) AD group | ||||
|---|---|---|---|---|
| MRI brain region | Protein | Correlation coefficient∗ | Significance (2-tailed) | df |
| Ventricular volume | A1AT | 0.24 | 0.01 | 119 |
| NSE | 0.16 | 0.03 | 169 | |
| Mean hippocampal volume | BDNF | −0.21 | 0.02 | 123 |
| ApoC3 | −0.18 | 0.02 | 168 | |
| ApoA1 | −0.15 | 0.04 | 169 | |
| ApoE | −0.15 | 0.05 | 169 | |
| Right entorhinal thickness | n/a | n/a | n/a | n/a |
| Left entorhinal thickness | n/a | n/a | n/a | n/a |
| Mean entorhinal volume | ApoC3 | −0.20 | 0.01 | 168 |
| ApoE | −0.18 | 0.02 | 169 | |
| Mean entorhinal thickness | ApoC3 | −0.22 | 0.01 | 168 |
| ApoA1 | −0.21 | 0.01 | 169 | |
| ApoE | −0.2 | 0.01 | 169 | |
| Prealbumin | −0.15 | 0.05 | 158 | |
| Whole-brain volume | ApoE | −0.19 | 0.02 | 145 |
| ApoA1 | −0.19 | 0.02 | 145 | |
| AB40 | 0.17 | 0.04 | 141 | |
Abbreviations: MRI, magnetic resonance imaging; MCI, mild cognitive impairment; AD, Alzheimer’s disease; NSE, neuron-specific enolase; RANTES, Regulated on Activation, Normal T Cell Expressed and Secreted; n/a, no significant association observed.
∗
Pearson's correlation coefficient.