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(a) Schematic representation of the identified domains in the Akr1p sequence. Ankyrin repeats are shown in the grid region; the six transmembrane domains are indicated in grey and the DHHC domain is highlighted in black; (b) Schematic representation of Akr1p membrane topology. Both ankyrin repeats and the DHHC-cysteine rich domain (CRD) are positioned on the cytoplasmic side of the membrane.
