Table 2. Four different types of substrate proteins that are palmitoylated.

Although many palmitoylated proteins have been identified, the recognition signals in these proteins remain poorly defined. In addition to the palmitoyl modification, proteins may contain other membrane interactions, such as a transmembrane domain or a second lipid modification (prenyl or myristoyl group). Palmitoylation sites are identified with a *.

palmitoylation type	substrate proteins
palmitoylation + prenylation −CXC*aaX	Ras proteins, Rho Proteins, Gγ subunits of S. cerevisiae
palmitoylation + myristoylation MGC*−	Gα subunits, Src family kinases (Yes, Fyn, Lck)
proximal to TMDs	GPCRs, viral-envelope proteins (HIV, influenza)
palmitoylation alone	Gα subunits, GRKs, RGS, SNAP-25, PSD-95