Table 3. Frequency of various haplotypes composed of Tag ID rs1800498 intron 2 (C/T), Tag IB rs1079597 intron 1 (A/G), and Tag IA rs1800497 Ex8 (A1/A2) SNPs of DRD2 receptor gene and ANKK1 gene in alcohol dependent subjects with a history of at least one suicidal attempt (n = 61) and in individuals in whom alcohol dependence was not associated with suicidal behavior (n = 108).
Haplotype | Haplotype Score | p-value | Haplotype frequency | No suicidal behavior | Suicidal behavior |
T-A-A1 | −1.427 | 0.153 | 0.020 | 0.033 | - |
T-G-A1 | −1.288 | 0.197 | 0.021 | 0.029 | 0.008 |
C-G-A2 | −1.286 | 0.198 | 0.261 | 0.291 | 0.213 |
C-A-A1 | −1.012 | 0.311 | 0.177 | 0.189 | 0.155 |
T-G-A2 | 2.705 | 0.006 * | 0.509 | 0.446 | 0.614 |
Hap-score determines a relationship between a specific haplotype and particular phenotypic quality.
*significance maintained after the Bonferroni correction was included.
power = 0.580.