Table 1. Comparison of human CD4 and CD8 T-lymphocyte epitope sequences between respiratory syncytial virus Memphis-37 and A2 strains.
RSV protein | Amino acid position | Peptide sequence* | % Homology between peptides | ||||
RSV-Memphis-37 | RSV-A2 | ||||||
CD4 | G | 162−175 | DFHFEVFNFVPCSI | DFHFEVFNFVPCSI | 100 | ||
F | 7−30 | KTNAITTILAAVTLCFASSQNITE | KANAITTILTAVTFCFASGQNITE | 83 | |||
F | 25−42 | SQNITEEFYQSTCSAVSK | GQNITEEFYQSTCSAVSK | 94 | |||
F | 43−60 | GYLSALRTGWYTSVITIE | GYLSALRTGWYTSVITIE | 100 | |||
F | 49−72 | RTGWYTSVITIELSNIKENKCNGT | RTGWYTSVITIELSNIKENKCNGT | 100 | |||
F | 55−72 | SVITIELSNIKENKCNGT | SVITIELSNIKENKCNGT | 100 | |||
F | 73−90 | DAKVKLIKQELDKYKNAV | DAKVKLIKQELDKYKNAV | 100 | |||
F | 85−102 | KYKNAVTELQLLMQSTPA | KYKNAVTELQLLMQSTPP | 94 | |||
F | 109−132 | RELPRFMNYTLNNTKNNNVTLSKK | RELPRFMNYTLNNAKKTNVTLSKK | 88 | |||
F | 175−192 | NKAVVSLSNGVSVLTSKV | NKAVVSLSNGVSVLTSKV | 100 | |||
F | 193−210 | LDLKNYIDKQLLPIVNKQ | LDLKNYIDKQLLPIVNKQ | 100 | |||
F | 229−252 | RLLEITREFSVNAGVTTPVSTYML | RLLEITREFSVNAGVTTPVSTYML | 100 | |||
F | 265−288 | PITNDQKKLMSNNVQIVRQQSYSI | PITNDQKKLMSNNVQIVRQQSYSI | 100 | |||
F | 295−318 | EVLAYVVQLPLYGVIDTPCWKLHT | EVLAYVVQLPLYGVIDTPCWKLHT | 100 | |||
F | 337−360 | TDRGWYCDNAGSVSFFPQAETCKV | TDRGWYCDNAGSVSFFPQAETCKV | 100 | |||
F | 391−408 | YDCKIMTSKTDVSSSVIT | YDCKIMTSKTDVSSSVIT | 100 | |||
F | 409−426 | SLGAIVSCYGKTKCTASN | SLGAIVSCYGKTKCTASN | 100 | |||
F | 427−444 | KNRGIIKTFSNGCDYVSN | KNRGIIKTFSNGCDYVSN | 100 | |||
F | 457−486 | YYVNKQEGKSLYVKGEPIINFYDPLVFPSD | YYVNKQEGKSLYVKGEPIINFYDPLVFPSD | 100 | |||
F | 493−516 | SQVNEKINQSLAFIRKSDELLHNV | SQVNEKINQSLAFIRKSDELLHNV | 100 | |||
F | 517−534 | NVGKSTTNIMITTIIIVI | NAGKSTTNIMITTIIIVI | 94 | |||
F | 541−558 | LIAVGLFLYCKARSTPVT | LIAVGLLLYCKARSTPVT | 94 | |||
CD8 | F | 8−17 | TNAITTILAA | ANAITTILTA | 80 | ||
F | 93−102 | LQLLMQSTPA | LQLLMQSTPA | 100 | |||
F | 106–113 | RARRELPRF | RARRELPRF | 100 | |||
F | 109–118 | RELPRFMNYT | RELPRFMNYT | 100 | |||
F | 260–269 | LINDMPITND | LINDMPITND | 100 | |||
F | 273–282 | LMSNNVQIVR | LMSNNVQIVR | 100 | |||
F | 285–294 | SYSIMSIIKE | SYSIMSIIKE | 100 | |||
F | 374–383 | TLPSEVNLCN | TLPSEVNLCN | 100 | |||
F | 388–397 | NPKYDCKIMT | NPKYDCKIMT | 100 | |||
F | 519–528 | GKSTTNIMIT | GKSTINIMIT | 90 | |||
F | 521–530 | STTNIMITTI | STINIMITTI | 90 | |||
F | 542–550 | IAVGLFLYC | IAVGLLLYC | 89 | |||
N | 46–59 | KLCGMLLITEDANH | KLCGMLLITEDANH | 100 | |||
N | 232–245 | STRGGSRVEGIFAG | STRGGSRVEGIFAG | 100 | |||
N | 250–263 | AYGAGQVMLRWGVL | AYGAGQVMLRWGVL | 100 | |||
N | 253–266 | AGQVMLRWGVLAKS | AGQVMLRWGVLAKS | 100 | |||
N | 256–269 | VMLRWGVLAKSVKN | VMLRWGVLAKSVKN | 100 | |||
N | 298–311 | AGFYHILNNPKASL | AGFYHILNNPKASL | 100 | |||
N | 306–314 | NPKASLLSL | NPKASLLSL | 100 | |||
M | 195–203 | IPYSGLLLV | IPYSGLLLV | 100 | |||
M | 229–237 | YLEKESIYY | YLEKESIYY | 100 | |||
M2-1 | 64–72 | AELDRTEEY | AELDRTEEY | 100 | |||
M2-1 | 151–159 | RLPADVLKK | RLPADVLKK | 100 | |||
NS1 | 41–49 | LAKAVIHTI | LAKAVIHTI | 100 |
Legend: *Differences between Memphis-37 and RSV A2 are bolded.