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Determination of the Concentration of Hydromorphone in Ammonium Sulfate at pH 5.5
| Sample | Peak Area
|
|||
|---|---|---|---|---|
| Sample 1 | Sample 2 | Sample 3 | Average | |
| 0.05 mg/mL | 6.37 | 6.3534 | ND | 6.3617 |
| 0.1 mg/mL | 12.43 | 11.91 | ND | 12.17 |
| 0.5 mg/mL | 57.6 | 57.9 | ND | 57.75 |
| Unknown | 7.733 | 7.734 | 7.334 | 7.600 |
Thirty milligrams of hydromorphone hydrochloride was suspended in 0.5mL 120mM ammonium sulfate, pH 5.5, sedimented, diluted 1000-fold, and measured using HPLC.
The concentration was found to be 60.43 mg/mL.
