Table 1.
Description of included inflammatory disorders
| Inflammatory disorder | Inclusion criteria | Exclusion criteria |
|---|---|---|
| Crohn’s disease | Compatible endoscopic and histopathologic findings | - |
| Exacerbation | ||
| Before first TNFα-antagonist infusion | ||
| Rheumatoid arthritis | Fulfilling the 2010 ACR RA and 1987 RA criteria | - |
| DAS28 >3.2 | ||
| Gout | Acute arthritis | - |
| Urate crystal positive or previously diagnosed gout | ||
| Autoinflammatory syndrome | Known history of autoinflammatory disorder | - |
| Typical attack | ||
| Pancreatitis [20] | Acute characteristic epigastric pain | HIV |
| SIRS [17] | Neutropenia (<1000/mm3) | |
| Serum and urinary amylase levels ≥3 x ULN | Chronic corticosteroid use | |
| Compatible imaging (CT or ultrasound) findings | ||
| Infectious mononucleosis [16] | Compatible clinical signs | - |
| EBV (VCA) or CMV IgM positive | ||
| Measles [15] | Febrile rash | - |
| Measles IgM positive | ||
| Viral respiratory tract infection | Symptoms/signs of respiratory tract infection | Positive sputum or blood culture |
| Positive PCR from respiratory tract secretions | ||
| Respiratory co-infections | Symptoms/signs of respiratory tract infection | - |
| Positive PCR from respiratory tract secretions | ||
| Positive sputum or blood culture | ||
| Bacterial sepsis [17] | International sepsis definition [17] | HIV |
| Neutropenia (<1000/mm3) | ||
| Candidemia [19] | Positive blood culture for Candida | - |
Abbreviations: ACR American College of Rheumatology, RA rheumatoid arthritis, DAS28 disease activity score, ULN upper limit of normal, EBV Epstein-Barr virus, VCA viral capsid antigen, CMV cytomegalovirus, ICU intensive care unit.