Table 1.
Early treated children with different time to HIV viral rebound
| Parameters | Mississippi [2] | Canadian [4] | Milan [5] |
|---|---|---|---|
| Time to viral rebound | 27 months | <1 month | <1 month |
| ART onset | 30 hours | <24 hours | 12 hours |
| Pre-ART HIV RNA. copies/ml | 19,812 | 808 | 152,560 |
| Time to HIV RNA <50 copies/ml on ART | 1 month | 6 months | 3 months |
| Time on ART before interruption | 18 months | 3 years | 3 years |
| Cell-associated HIV DNA | Undetecteda | Undetected | Undetected |
| Replication-competent virus | Negative viral outgrowth assaya | Negative viral outgrowth assay | Negative viral culture |
| HIV antibody | Non-reactivea | Non-reactive | Non-reactive |
| HIV-specific T cells | Undetecteda | Not reported | Detected |
| Others | Normal frequencies of activated T cellsa | Detected cell-associated HIV RNA | High frequencies of activated T cells |
a
The reservoir and immunity testing in the Mississippi baby were performed after ART was interrupted. The testing on the Canadian and Milan babies was performed during ART. ART: antiretroviral therapy.