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. 2014 Nov 20;16(11):972–981. doi: 10.1016/j.neo.2014.09.008

Table 1.

Effect of E7080 on cell viability of human CRC cells and human umbilical vein endothelial cells (HUVEC).

IC50 values were determined following E7080 treatment for 72 hours in media with low serum (1% (v/v) FCS). Cell lines are arranged according to increasing IC50 values. Shown are the results as mean and 95% confidence interval (CI) of IC50 of at least three independent proliferation assays with hexaplicates. IC50 values and 95% CI were determined using GraphPad Prism software. See also Fig. 1A.Wild-type (wt) KRAS and mutated (mut) KRAS were determined with Sanger Catalogue of somatic mutations in cancer (COSMIC) database.

(http://cancer.sanger.ac.uk/cancergenome/projects/cosmic/).

Cell lines KRAS status IC50 (μmol/l) 95% CI (μmol/l)
CaCo2 wt > 1000 ¯¯¯¯
Colo741 wt > 1000 ¯¯¯¯
SW620 mut 548 273-111
HT29 mut 431 299-620
HCT116 mut 399 296-538
T84 mut 276 179-427
SW480 mut 240 183-313
Colo678 wt 222 175-283
LS174T mut 144 96-215
HCT15 mut 120 91-158
HUVEC wt 22 14-36