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Pancreatic neoplasms inNeurog3-Tsc1−/− mice. (A) Abdominal swelling and palpable mass were observed in Neurog3-Tsc1−/− mice (TN), but not in wild-type littermates (WT). (B) Pancreatic tumor incidence and survival rate (C) for Neurog3-Tsc1−/− (n = 25) and wildtypemice (n = 15) analyzed by Kaplan-Meier. (D) Gross photograph of multi-nodular pancreatic tumors. T, L, and S indicate tumor, liver, and spleen, respectively. (E) Tumor size. Tumor size was measured at the week of 45.
