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. 2014 Nov 20;16(11):928–938. doi: 10.1016/j.neo.2014.09.003

Figure 2.

Figure 2

Tumor progression in a mouse orthotopic xenograft model. (A) Dorsal tongue of mouse was stained with H&E (original magnification, × 40; scale bar, 2 mm). Tumor volume of OSCC was assessed by two-dimensional measurements. (B) Dorsal tongue of mouse was stained with PCNA (original magnification, × 500; scale bar, 200 μm). PCNA index was established to quantitatively analyze the proliferative activity of xenografted tumor tissues. The micrographs shown in this figure are representative of five independent tissues that showed similar results. The results are shown as mean values ± SD (n = 5) and were analyzed by the Mann-Whitney U test (*P < .05 and **P < .01).