Table 3.
The association between serum uric acid level and all-cause or cardiovascular mortality in women.
| Seum uric acid, mg/dL |
Number Of Subjects |
Person- years |
Deaths | Mortality per 1000 person- years |
Age- Adjusted hazard ratio (95% CI) |
Multivariate- adjusted* hazard ratio (95% CI) |
|---|---|---|---|---|---|---|
| ALL WOMEN (N=3137) | ||||||
| All cause mortality | ||||||
| 0–3.8 | 758 | 10,998 | 78 | 7.1 | 1 | 1 |
| >3.8–4.5 | 740 | 10,413 | 104 | 10.0 | 1.26 (0.85–1.86) | 1.25 (0.84–1.88) |
| >4.5–5.4 | 756 | 10,238 | 148 | 14.5 | 1.41 (1.07–1.86) | 1.39 (0.98–1.98) |
| >5.4 | 883 | 11,286 | 258 | 22.9 | 1.69 (1.23–2.32) | 1.39 (0.90–2.15) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.22 (1.12–1.32) | 1.17 (1.03–1.32) |
| Cardiovascular mortality | ||||||
| 0–3.9 | 758 | 10,998 | 24 | 2.2 | 1 | 1 |
| >3.9–4.5 | 740 | 10,413 | 31 | 3.0 | 1.18 (0.48–2.89) | 1.51 (0.58–3.91) |
| >4.5–5.4 | 756 | 10,238 | 54 | 5.3 | 1.61 (0.74–3.51) | 2.16 (0.80–5.85) |
| >5.4 | 883 | 11,286 | 102 | 9.0 | 2.25 (1.01–5.0) | 2.64 (0.90–7.76) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.28 (1.13–1.46) | 1.23 (1.01–1.51) |
| POSTMENOPAUSAL WOMEN (N=1274) | ||||||
| All-cause mortality | ||||||
| 0–4.3 | 316 | 4084 | 106 | 26 | 1 | 1 |
| >4.3–5.0 | 311 | 3893 | 124 | 32 | 1.14 (0.74–1.76) | 1.33 (0.83–2.14) |
| >5.0–5.9 | 303 | 3754 | 121 | 32 | 1.26 (0.88–1.79) | 1.25 (0.79–1.99) |
| >5.9 | 344 | 3940 | 167 | 42 | 1.71 (1.21 | 1.58 (0.90–2.77) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.24 (1.11–1.39) | 1.22 (1.06–1.40) |
| Cardiovascular mortality | ||||||
| 0–4.3 | 316 | 4084 | 42 | 10 | 1 | 1 |
| >4.3–5.0 | 311 | 3893 | 40 | 10 | 0.96 (0.53–1.74) | 1.21 (0.55–2.64) |
| >5.0–5.9 | 303 | 3754 | 48 | 13 | 1.41 (0.70–2.84) | 1.50 (0.62–3.62) |
| >5.9 | 344 | 3940 | 66 | 17 | 1.97 (1.09–3.56) | 1.94 (0.71–5.27) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.31 (1.14–1.51) | 1.31 (1.03–1.66) |
| PREMENOPAUSAL WOMEN (N=1863) | ||||||
| All-cause mortality | ||||||
| 0–3.7 | 442 | 6647 | 13 | 2.0 | 1 | 1 |
| >3.7–4.4 | 486 | 7156 | 20 | 2.8 | 1.72 (0.73–4.1) | 1.71 (0.62–4.73) |
| >4.4–5.1 | 486 | 7087 | 15 | 2.1 | 1.16 (0.46–2.93) | 1.01 (0.32–3.16) |
| >5.1 | 449 | 6375 | 22 | 3.5 | 1.53 (0.54–4.27) | 0.80 (0.26–2.47) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.30 (0.91–1.84) | 1.13 (0.84–1.53) |
| POSTMENOPAUSAL WOMEN ON HRT (N=480) | ||||||
| All-cause mortality | ||||||
| 0–4.3 | 120 | 1572 | 35 | 22 | 1 | 1 |
| >4.3–5.0 | 132 | 1736 | 43 | 25 | 1.19 (0.67–2.12) | 1.76 (0.94–3.28) |
| >5.0–5.9 | 111 | 1453 | 34 | 23 | 0.89 (0.48–1.64) | 0.81 (0.32–2.09) |
| >5.9 | 117 | 1444 | 38 | 26 | 1.30 (0.75–2.24) | 0.95 (0.31–2.90) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.11 (0.98–1.25) | 1.12 (0.86–1.46) |
| Cardiovascular mortality | ||||||
| 0–4.3 | 120 | 1572 | 15 | 9.5 | 1 | 1 |
| >4.3–5.0 | 132 | 1736 | 17 | 9.8 | 1.38 (0.56–3.39) | 1.75 (0.50–6.03) |
| >5.0–5.9 | 111 | 1453 | 14 | 9.6 | 1.19 (0.40–3.55) | 0.65 (0.13–3.20) |
| >5.9 | 117 | 1444 | 13 | 9.0 | 1.42 (0.56–3.59) | 0.60 (0.15–2.39) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.13 (0.92–1.39) | 0.99 (0.77–1.28) |
| POSTMENOPAUSAL WOMEN NOT ON HRT (N=794) | ||||||
| All-cause mortality | ||||||
| 0–4.3 | 196 | 2512 | 71 | 28 | 1 | 1 |
| >4.3–5.0 | 179 | 2157 | 81 | 38 | 1.14 (0.65–2.01) | 1.18 (0.64–2.18) |
| >5.0–5.9 | 192 | 2300 | 87 | 38 | 1.52 (0.99–2.34) | 1.35 (0.69–2.62) |
| >5.9 | 227 | 2496 | 129 | 52 | 1.97 (1.32–2.96) | 1.89 (0.99–3.62) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.29 (1.18–1.41) | 1.30 (1.11–1.51) |
| Cardiovascular mortality | ||||||
| 0–4.3 | 196 | 2512 | 27 | 11 | 1 | 1 |
| >4.3–5.0 | 179 | 2157 | 23 | 11 | 0.71 (0.31–1.65) | 1.05 (0.40–2.76) |
| >5.0–5.9 | 192 | 2300 | 34 | 15 | 1.61 (0.74–3.52) | 1.66 (0.76–3.59) |
| >5.9 | 227 | 2496 | 53 | 21 | 2.43 (1.36–4.37) | 3.15 (1.21–8.23) |
| SUA per mg/dL | N/A | N/A | N/A | N/A | 1.48 (1.28–1.71) | 1.61 (1.33–1.94) |
*
Adjusted forage, race/ethnicity, menopausal status, smoking, alcohol consumption, educational attainment, physical activity, body mass index, waist-to-hip ratio, serum C-reactive protein, plasma triglyceride, total cholesterol, and HDL cholesterol, use of aspirin, NSAIDs, and diuretics, consumption of coffee, meat, fish, dairy, and sugar-sweetened beverage consumption, use of hormone replacement therapy (except in premenopausal women), diabetes, insulin resistance, systolic blood pressure, diastolic blood pressure, use of antihypertensives, glomerular filtration rate and urine albumin-creatinine ratio.