Table 3.

Multivariate Cox regression model for OS and EFS considering the (Y₉₆) model and clinical and biologically relevant parameters for risk stratification of set 3 patients

	Survival		Event
	HR (95% CI)	P	HR (95% CI)	P
Univariate model
Model (Y96)	28.09 (8.65–91.19)	<0.001	15.59 (7.07–34.34)	<0.001
Age	11.68 (5.40–25.27)	<0.001	5.44 (3.16–9.36)	<0.001
Model (Y96)	15.85 (4.75–52.91)	<0.001	11.07 (4.89–25.07)	<0.001
Age	5.41 (2.46–11.95)	<0.001	2.61 (1.49–4.59)	0.001
INSS stage	10.14 (5.1–20.16)	<0.001	6.27 (3.72–10.57)	<0.001
Model (Y96)	15.13 (4.41–51.97)	<0.001	10.32 (4.46–23.86)	<0.001
INSS stage	3.65 (1.78–7.5)	<0.001	2.48 (1.42–4.31)	0.001
MYCN	8.7 (4.7–16.1)	<0.001	4.7 (2.73–8.1)	<0.001
Model (Y96)	20.2 (6.02–67.73)	<0.001	13.53 (6–30.5)	<0.001
MYCN	2.74 (1.46–5.12)	0.002	1.59 (0.91–2.77)	0.105
1p LOH	7.48 (4.06–13.77)	<0.001	4.25 (2.57–7.03)	<0.001
Model (Y96)	18.92 (5.63–63.52)	<0.001	12.83 (5.67–29.01)	<0.001
1p LOH	2.93 (1.56–5.47)	0.001	1.76 (1.05–2.95)	0.033
Multivariate model
Model (Y96)	9.9 (2.8–35.3)	<0.001	836 (3.6–30.4)	<0.001
MYCW	3.2 (1.7–6.0)	<0.001	1.7 (0.99–3.0)	0.053
INSS stage	4.2 (2.0–8.4)	<0.001	2.6 (1.5–4.5)	0.001

NOTE: The analysis was conducted sequentially, adding one variable at each step, to assess how the presence of each variable influences the performance of the (Y₉₆) model. The (Y₉₆) model was statistically significantly associated with OS and EFS in univariate and multivariate analyses.

Abbreviation: NE, "non evaluable" P value due to "no cases" in a combination of the 2 factors.