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. 2014 Oct 20;592(Pt 22):5093–5107. doi: 10.1113/jphysiol.2014.275909

Figure 3. COX-1 inhibition in the VL-PAG results in a significant increase in firing thresholds to both C- and A-nociceptor activation.

Figure 3

A, digitised traces of raw data displaying responses of a moderate C+ve neuron to C-nociceptor activation, before and after administration of SC-560 into the VL-PAG. B, SC-560 administration into the VL-PAG resulted in an increase in response threshold of dorsal horn neurons to C-nociceptor activation compared to vehicle. C, digitised traces of raw data displaying responses of a moderate C+ve neuron to A–nociceptor activation, before and after administration of SC-560 into the VL-PAG. D, SC-560 administration into the VL-PAG resulted in an increase in response threshold of dorsal horn neurons to A-nociceptor activation compared to vehicle. Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, two-way ANOVA plus post hoc Bonferroni tests.