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. 2014 Oct 20;592(Pt 22):5093–5107. doi: 10.1113/jphysiol.2014.275909

Figure 6. Rostrocaudal site of injection of SC-560 within the PAG does not influence the degree of inhibition of A- or C-nociceptor-evoked responses.

Figure 6

A, injection sites within the VL-PAG: sites of SC-560 injection tested on slow ramps only (•), fast only (▾), or both (▪); vehicle sites tested on both fast and slow heat ramps (□); coordinates are relative to Bregma (DM, dorsomedial; DL, dorsolateral; L, lateral; VL, ventrolateral). B, there was no correlation between the rostrocaudal location of the injection sites within the PAG and the overall change over time (AUC) in neuronal firing thresholds to A- and C-nociceptor activation produced by intra-VL-PAG injection of SC-560 (r = 0.23, n = 19, P = 0.33; Spearman's correlation) or vehicle (r = −0.3, n = 12, P = 0.2). Note that some injection sites are overlapping.