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. 2014 Jul 31;12(8):1229–1233. doi: 10.1111/jth.12629

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© 2014 Crown copyright. Journal of Thrombosis and Haemostasis published by Wiley Periodicals Inc. on behalf of the International Society on Thrombosis and Haemostasis.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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(A) Specific activities (IU μg⁻¹) of native sequence recombinant streptokinase (rSK) and an engineered variant with an amino-terminal methionine (rSK-Met), measured in three different assay systems: a chromogenic assay, a fibrin clot overlay assay and a fibrin clot lysis assay. All potency estimates were calculated relative to the WHO 3rd International Standard for Streptokinase (00/464) using a parallel line bioassay model. (B) Potency estimates for 11 batches of commercial streptokinase from two different manufacturers, based on chromogenic and fibrin clot overlay assay methods and presented as a percentage of the labeled potency.