Table 1.
Demographics and Baseline Characteristics of the Participants with Normal and Impaired Renal Function
| Normal renal function (n = 8) | Mild renal impairment (n = 12) | Moderate renal impairment (n = 9) | |
|---|---|---|---|
| CLCR, mL/min | |||
| Mean (SD) | 99.5 (12.6) | 67.1 (9.4) | 42.5 (4.4) |
| Age, years | |||
| Mean (SD) | 61 (5) | 64 (10) | 63 (10) |
| Median (range) | 61 (55–69) | 67.5 (46–75) | 68 (46–71) |
| Sex, n (%) | |||
| Male | 2 (25) | 3 (25) | 3 (33) |
| Female | 6 (75) | 9 (75) | 6 (67) |
| Race, n (%) | |||
| White | 7 (88) | 9 (75) | 7 (78) |
| Black or African-American | 1 (13) | 3 (25) | 2 (22) |
| Weight, kg | |||
| Mean (SD) | 75.5 (10.6) | 76.7 (15.9) | 84.8 (19.8) |
| Height, cm | |||
| Mean (SD) | 164.5 (5.7) | 165.3 (8.3) | 163.1 (9.0) |
| Body mass index, kg/m2 | |||
| Mean (SD) | 27.9 (3.6) | 27.9 (4.0) | 31.7 (5.9) |
CLCR, creatinine clearance using the Cockcroft–Gault equation; SD, standard deviation.