. 2014 Aug 28;171(18):4255–4272. doi: 10.1111/bph.12782

Table 2.

Summary of ex vivo occupancies in the rat and in vitro binding affinities of vortioxetine

Target	Ex vivo occupancy in the rat ED₅₀ (mg·kg⁻¹) [95% CI]	In vitro binding affinity, K_i (nM)
Target	Ex vivo occupancy in the rat ED₅₀ (mg·kg⁻¹) [95% CI]	Rat	Human
5-HT₃	0.004 [0.0016–0.011]	1.1	3.7
5-HT₇	NC	190	19
5-HT_1D	ND	3.7	54
5-HT_1B	2.3 [1.7–3.2]	16	33
5-HT_1A	NC	230	15
SERT	0.3 [0.24–0.37]	8.6	1.6

The ex vivo occupancy ED₅₀ values in the rat were derived based on occupancy–dose curves of vortioxetine for the 5-HT₃, 5-HT₇, 5-HT_1B, 5-HT_1A receptors and the SERT as shown in Figure 1. The previously published in vitro binding affinities (Bang-Andersen et al., 2011; Mørk et al., 2012) are also shown in order to highlight the species differences for some of the targets. NC, not calculated due to limited range; ND, not determined.