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GYY4137 treatment did not affect mitochondrial functions. No significant differences in basal respiration, ATP production, spare respiratory capacity and proton leak were observed in (A) MCF7 and (B) MCF10A treated with GYY4137 for 24 h. OCR, oxygen consumption rate. Oligomycin, 1 μM; carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP), 1.5 μM; rotenone (Rot)/antimycin A (AA), 1 μM; NT, non-treated; ZYJ1122 and GYY4137, 400 μM (n = 8). Results are mean ± SD.
