Figure 4.
H2S triggers intracellular acidification in cancer but not non-cancer cells. (A) pH measurements of MCF7 and HepG2 using ratiometric confocal microscopy showed a significant decrease in intracellular pH (pHi) in GYY4137-treated samples, both visually with microscope (pictures on top) and quantitatively (graph below). (B) No significant change in pHi in different treatments was observed in normal cells MCF10A and WI38. NT, non-treated. ZYJ1122 and GYY4137, 400 μM. (n ≥ 50 cells per group), *P < 0.05. Results are mean ± SD.