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. 2014 Jul 2;171(18):4322–4336. doi: 10.1111/bph.12773

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Reduced pH response capacity in cancer cells upon H₂S exposure. (A) Alkali response and (B) acid response curves of MCF7 and HepG2. GYY4137-treated cancer cells showed reduced responses of the signature alkali peak (indicated by arrow) as observed in NT and ZYJ1122 negative control. GYY4137-treated samples showed slow and minimal recovery of pH_i (indicated by the inset ) upon re-introduction of sodium (Na⁺) buffer as compared to NT and ZYJ1122-treated cells. (C) H₂S treatment did not affect the expression levels of pH regulators. No significant differences in transcript level of AE2 and NHE1 pH regulators in HepG2 and MCF7 upon exposure of H₂S. NT, non-treated. ZYJ1122 and GYY4137, 400 μM (n = 3). Results are mean ± SD.

Inline graphic — Reduced pH response capacity in cancer cells upon H₂S exposure. (A) Alkali response and (B) acid response curves of MCF7 and HepG2. GYY4137-treated cancer cells showed reduced responses of the signature alkali peak (indicated by arrow) as observed in NT and ZYJ1122 negative control. GYY4137-treated samples showed slow and minimal recovery of pH_i (indicated by the inset ) upon re-introduction of sodium (Na⁺) buffer as compared to NT and ZYJ1122-treated cells. (C) H₂S treatment did not affect the expression levels of pH regulators. No significant differences in transcript level of AE2 and NHE1 pH regulators in HepG2 and MCF7 upon exposure of H₂S. NT, non-treated. ZYJ1122 and GYY4137, 400 μM (n = 3). Results are mean ± SD.