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. 2014 Jul 2;171(18):4322–4336. doi: 10.1111/bph.12773

Figure 6.

Figure 6

An increase in lactate production or inhibition of pH regulator(s) alone was insufficient to cause intracellular acidification and cancer cell death. (A) High lactate production (left) induced by the mitochondrial inhibitors, rotenone (Rot, 2 μM) and/or antimycin A (AA, 2 μM) did not cause a significant decrease in pHi (right). *P < 0.05. (B) No significant effects on MCF7 and HepG2 cancer cell survival were observed even with increasing concentrations of DIDS and/or cariporide (Cari) inhibition of pH regulator(s). (C) pH regulator inhibition resulted in less substantial pHi changes as compared to GYY4137-treated cells. NT, non-treated. DIDS, 50 μM; cariporide (Cari), 0.05 mg·mL−1 (n ≥ 50 cells per group). Results are mean ± SD.