Figure 1.
Sequence analysis, secondary structure elements, and overall structure of AKR5C3. (A) Sequence and secondary structure of AKR5C3. The secondary structure diagram for AKR5C3 is shown at the top of the sequence. The α-helices and β-strands are indicated. Conserved catalytic tetrad DYKH are highlighted with red asterisks. (B) Stereo-view cartoon representation of AKR5C3 apoform showing the typical (β/α)8 fold. Two molecules of a dimer are colored in orange and cyan, respectively. An interactive view is available in the electronic version of the article.