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Kinetic Constants of AKR5C3, AKR5C3-D53A, and AKR5C3-R192G
| Apparent kinetic parameters | Km-NADPH (mM) | kcat (s−1) | kcat/Km (s−1 mM−1) | Km-Butanedione (mM) | kcat (s−1) | kcat/Km (s−1 mM−1) |
|---|---|---|---|---|---|---|
| AKR5C3 | 0.36 | 349.54 | 970.94 | 4.62 | 42.80 | 9.26 |
| AKR5C3-D53A | 0.04 | 104.22 | 2605.50 | 6.39 | 77.82 | 12.18 |
| AKR5C3-R192G | 0.67 | 18.67 | 27.87 | 1.08 | 75.49 | 69.90 |
