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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Genes Brain Behav. 2014 Sep 29;13(8):743–757. doi: 10.1111/gbb.12175

Figure 2. Differentially Expressed Probesets, and Probesets Displaying Reduced Variance of Expression During Selection for HAP3 and LAP3 Mice.

Figure 2

Brain gene expression was determined using Affymetrix MOE430 v2 arrays from 4–5 mice at each generation. Following normalization and filtering for expression above background, differences in expression at each generation, that were maintained throughout selection (until generation 13), were determined using a moderated t-test (Panel A). Similarly, probesets that displayed reduced variance of expression, compared to generation 0 (HS mice), and that maintained that reduced variance throughout selection, were determined (Panels B and C). The cumulative number of probesets that displayed these characteristics at each generation of selection is indicated. Colors indicate the generation of which differential expression or reduced variance began.