Table 2.
Priority Genes With Expression Differences from Selective Breeding For Alcohol Preference
| Gene Symbol | Gene Name | QTL (SNP) associated in multivariate modela (chromosome: Mb range) | Proportion of variance in the gene’s expression explained by multivariate model | Generation Where Significant Differential Expression Began | Generation Where Significant Reduced Variation Began (Line of RV) | Physical Location of Probe Set | Location of Major eQTL [chromosome: Mb (p-value)] | Difference in Expression at Generation 13 [log2 HAP3/LAP3 (p-value)] |
|---|---|---|---|---|---|---|---|---|
| Gnb1 | guanine nucleotide binding protein (G protein), beta 1 | rs13478067 (4:144.37 - 165.38) | 0.74 | 6 | 6 (LAP) | 4:154.93 Mb | 4:155.24 Mb (<0.0001) | −1.98 (<0.0001) |
| Usp53 | ubiquitin specific peptidase 53 | rs13477323 (3:99.4 - 151.7) rs13478067 (4:144.37 - 165.38) |
0.73 | 6 | 6 (LAP) | 3:122.69 Mb | 3:118.29 Mb (<0.0001) | −0.47 (<0.0001) |
| Peg3 | paternally expressed 3 | rs3669485 (1:3.98 - 30.77) | 0.14 | 8 | 6 (HAP) | 7:6.66 Mb | 3:23.72 Mb (0.0920) | 1.33 (0.0009) |
| Fam168a | familiy sequence similarity 168, member A | rs3669485 (1:3.98 - 30.77) | 0.20 | 8 | 8 (HAP) | 7:107.99 Mb | 7:103.13 Mb (<0.0001) | 1.2 (<0.0001) |
| Acer3 | alkaline ceramidase 3 | rs13479416 (7:85.16 - 131.84) | 0.98 | 13 | 8 (HAP) | 7:105.36 Mb | 7:103.13 Mb (<0.0001) | 1.46 (<0.0001) |
| Ccnh | cyclin H | rs6241342 (7:116.33 - 136.33) | 0.15 | 6 | 13:85.35 Mb | 8:14.76 Mb (0.2070) | 0.13 (0.0749) | |
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | rs3701432 (4:19.19 - 44.04) rs13478067 (4:144.37 - 165.38) |
0.50 | 6 | 4:32.11 Mb | 4:31.65 Mb (0.0260) | −0.39 (0.0004) | |
| Mphosph9 | M-phase phosphoprotein 9 | rs13477323 (3:99.4 - 151.7) | 0.25 | 6 | 5:124.7 Mb | 5:119.76 Mb (0.0370) | −1.13 (<0.0001) | |
| Vps41 | vacuolar protein sorting 41 (yeast) | rs6241342 (7:116.33 - 136.33) | 0.15 | 6 | 13:18.92 Mb | 12:82.69 Mb (0.6730) | −0.35 (0.0001) | |
| Xaf1 | XIAP associated factor 1 | rs13478067 (4:144.37 - 165.38) rs6241342 (7:116.33 - 136.33) |
0.28 | 6 | 11:72.13 Mb | 11:69.42 Mb (<0.0001) | −0.42 (0.0002) | |
| Odz4 | odd Oz/ten-m homolog 4 (Drosophila) | rs13479416 (7:85.16 - 131.84) | 0.20 | 13 | 7:104.06 Mb | 7:117.12 Mb (0.3440) | −0.92 (<0.0001) |
a
priority QTLs (deeQTLs shown in Table 1) are represented in red