Figure 4.

General memory impairment in mice with a mutation of Dcdc2. (a) Analysis of total errors (working correct, reference, and working incorrect) made across 14 test sessions indicate that Dcdc2^del2/del2 mice made significantly more errors, overall, across all 14 test sessions. (b) Within test session analysis of total errors across trials reveal that Dcdc2^del2/del2 subjects made significantly more errors in the maze across trials than wild type controls. Specifically, as the cognitive load of the task increased (number of remaining escape platforms decreases). (c) Further examination by error type found that Dcdc2^del2/del2 mice made significantly more working memory correct (c) and reference memory (d) errors in comparison to WT mice, but were comparable in the amount of working memory incorrect errors performed (e). *P<0.05; **P<0.01