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Representative photomicrographs of a VitE responder pre- and post-treatment show decreased numbers of Shh+ hepatocytes (A and B, arrows, Shh is brown), decreased numbers of K8/18-negative hepatocytes/Ub+ foci (C and D, arrows, K8/18 is brown, Ub is red), and decreased ductular reaction (E and F, arrows, α-SMA is brown, gli-2 is red, and sox-9 is blue), with marked pericellular fibrosis (inset E) in the pre-treatment biopsy. All photos are at 400× magnification.
