Table 3.

Comparison of changes in immunohistochemical data with and without adjusting for baseline values: Placebo vs. Vitamin E groups.

Changes in:	Placebo (N=29)	Vitamin E (N=30)	p-value#	β±SE/ OR[95%CI]	p-value
Shh+ hepatocytes, cells/HPF	1.2±10.7	−3.0±8.3	0.048	−4.4±2.1	0.037
K8/18 negative cells or ubiquitin-positive foci/HPF	0.2±1.4	−2.9±1.3	0.082	−2.6±1.2	0.037
α-SMA+ stain score, 0 to 4	0 (0, 0)	0 (−1, 0)	0.097	1.8[0.6, 5.6]	0.34
Gli2/sox9+ stain score, 0 to 4	0 (0, 0)	0 (−1, 0)	0.068	1.7[0.5, 5.5]	0.36

Data were presented as mean ± SD for numeric variables and median (IQR) for ordinal variables. #: Wilcoxon Rank-Sum tests There were some cases with missing data: Shh-positive hepatocytes (N=2), K8/18 negative or ubiquitin-positive foci (N=14), α-SMA-positive stain score (N=1) and gli2/sox9-positive stain score (N=2). B-coefficients and SE were computed in multiple linear regression models, while cumulative odds ratios were computed in multiple ordinal logistic regression models, both of which were adjusted for baseline values.