Table 4.

Comparison of non-responders to responders.

	Non-responders				Responders				p-value#
	Combined VitE and Placebo (N=38)	Placebo (N=21)	Vitamin E (N=17)	p-value#	Combined VitE and Placebo (N=21)	Placebo (N=8)	Vitamin E (N=13)	p-value$
H&E Histologic changes
Steatosis	0[−1, 0.25]	0[−0.5, 1]	0[−2, 0]	0.0624	−1[−1.5, 0]	−0.5[−1, 0]	−1[−2, 0]	0.2819	0.0104
Lobular inflammation	0[−0.25, 0]	0[0, 0.5]	0[−1, 0]	0.1238	−1[−1,0]	−1[−1,0.25]§	−1[−1, 0]	0.7186	0.0003
Hepatocyte ballooning	0[0, 1]	0[0, 1]	0[0, 1]	0.8593	−1[−2, −1]	−1.5[−2 ,−1]§	−1[−1, −1]	0.1057	<0.0001
Mallory-Denk bodies	0[0, 0]	0[0, 0]	0[−1, 0]	0.2594	0[−1, 0]	0[−0.75, 0]	0[−1, 0]	0.5647	0.0311
Portal inflammation	0[0, 0]	0[0, 0]	0[0, 0]	0.9545	0[−0.5, 0]	0[0, 0.75]	0[−1, 0]§	0.0147	0.1859
Fibrosis	0[−1, 0.25]	0[0, 0]	0[−1, 1]	0.9748	0[−1, 0]	0[−1, 0]	0[−1, 0]	0.8006	0.1140
Biochemical changes
Serum ALT change, U/L	−11.2±47.8	0.2±30.3	−26.1±61.9	0.0215	−49.1±50.6	−32.8±40.5§	−59.2±55.0	0.4254	0.0078
Serum AST change, U/L	−1.6±34.3	9.4±29.8	−16.1±35.2	0.0205	−24.7±29.2	−12.9±23.5	−31.9±30.8	0.1282	0.0103
IHC parameter changes
Shh-positive hepatocytes, cells/HPF	0.74±10.3	2.6±12.2	−1.9±6.2	0.0464	−3.6±8.2	−2.4±2.9§	−4.3±10.2	0.7705	0.0067
K8/18 negative cells or ubiquitin-positive foci/HPF	−0.91±6.8	0.4±7.5	−2.5±5.7	0.1451	−2.5±5.9	−0.8±0.9	−3.5±7.3	0.5002	0.1556
α-SMA-positive stain score	0[0, 0]	0[0, 0]	0[0, 0]	0.3736	0[−1, 0]	0[0, 0]	0[−1, 0]	0.2388	0.0468
gli2/sox9-positive stain score	0[0, 0]	0[0, 0]	0[−1, 0]	0.0876	0[−1, 0]	0[−0.75, 0]	0[−1, 0]	0.7050	0.0805

^$: p-values for non-responders vs. responders (combined groups: vitamin E and placebo).

^#: p-values for placebo vs. vitamin E.

^§: p-value<0.05 vs. non-responders within the same treatment group.