Fig. 5.
Stimulated tissue engineered neocartilage constructs were implanted into a rabbit petallar-femoral defect for 3 weeks. Constructs were capable of being sutured into place and persisted until the 3 week sacrifice time. Rabbit in vivo implantation proof-of-concept. (a) Stimulated construct pre-implantation. (b) H&E staining of stimulated construct before implantation (40×). (c) (Left) Stimulated construct sutured into rabbit patellar osteochondral defect using a restorable 6-0 Vicryl, (Right) after 3 weeks in vivo. Sutures have begun resorbing as expected, while the stimulated construct is still in place within the defect. (d)H&E staining of stimulated construct within rabbit patellar defect after 3 weeks (4×).