Table 3.

Comparison of the numbers of eSS iterations for the branched pathway case study

eSS iterations	Noise-free data a			Noisy data b
	(s,o)=(3,3)	(s,o)=(5,3)	(s,o)=(3,5)	(s,o)=(3,3)	(s,o)=(5,3)	(s,o)=(3,5)
SPE-slope	6730	9144	8636	1440 ± 1045	753.6 ± 490.7	259.0 ± 94.9
IPE-slope	63	65	143	66.2 ± 7.2	87.0 ± 18.6	92.4 ± 69.7
IPE-ODE	75	305	225	76.6 ± 17.8	83.8 ± 33.2	92.6 ± 43.3
SPE-ODE	3827 c			787.8 ± 438.7
IFPE	112			67.0 ± 13.1
IFPE-ODE	156			70.2 ± 11.8

^aFor noise-free data, five independent runs were carried out. The number of eSS iterations corresponds to the run with the lowest objective function value.

^bFor noisy data, the reported values are the mean ± standard deviation of five technical replicates of the data.

^cOnly three out of five repeated runs finished within 24 hours. The number of eSS iterations corresponds to the run with the lowest objective function value among the three successful runs.