Figure 7. Eosinophil derived IL-10 preserves larvae.

(A) – (C), ΔdblGATA mice received PBS or 5 × 10⁶ eosinophils from infected IL-5Tg⁺ or IL-5Tg⁺IL-4^−/− mice every 48 h from 5 – 9 dpi. (A) Total body larval burdens in muscle, 28 dpi. (B) Number of CD4⁺IL-10⁺ cells and (C) CD4⁺IL-4⁺ cells in diaphragms of mice, 17dpi. (D) IL-10 detected in eosinophils recovered from dLNs and diaphragms of infected Vertx mice, 13dpi. (E) – (H), ΔdblGATA mice received 5 × 10⁶ eosinophils from infected WT or IL-10^−/− mice, or PBS every 48 h from 5 – 9 dpi. (E) Larval burdens in diaphragms, 17 dpi. (F) Numbers of CD4⁺IL-10⁺ cells and (G) CD4⁺IL-4⁺ cells in diaphragms of mice, 17 dpi. (H) NO endproducts in antigen-stimulated dLN cell cultures. Each data set was collected from two experiments with similar results. Values represent mean ± SD; n = 3 - 4 mice. Significant differences were determined by Student's t test or ANOVA and Tukey's test. *p < 0.05, **p < 0.001, ***p < 0.0001.