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. Author manuscript; available in PMC: 2014 Nov 23.
Published in final edited form as: Expert Opin Ther Targets. 2014 Jan 6;18(3):277–292. doi: 10.1517/14728222.2014.867946

Table 2.

Genes inactivated by deletion, mutation or epigenetic silencing.

Gene Location Start site Frequency Function Ref.
ARID1A/B 1p36.1 27,022 kb Del ~ 35% SWI/SNF chromatin remodeling protein [103]
ATRX Xq21 76,760 kb Mut 2.5% Chromatin remodeling protein [16,108,109]
CADM1 11q23 115,039 kb Del ~ 20% Cell adhesion molecule [104-107]
CAMTA1 1p36.31 6,845 kb Del ~ 35%% Calmodulin-binding transcription factor [83,84]
CASZ1 1p36.22 10,696 kb Del ~ 35% Zinc finger transcription factor [97-99]
CHD5 1p36.31 6,161 kb Del ~ 35% CHD chromatin remodeling protein [70,73-75]
KIF1B β 1p36.22 10,270 kb Del ~ 35% Kinesin 3 cytoplasmic transport protein [92,93,95,96]
miR-34a 1p36.22 9,211 kb Del ~ 35% Noncoding miRNA, targets MYCN [87-91]

Del: Deletion; Mut: Mutation.