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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Pediatr Nephrol. 2014 Jun 3;30(1):51–63. doi: 10.1007/s00467-014-2857-9

Figure 1. Schema for Integrative Genomics of NS.

Figure 1

To define the biologic mechanisms of NS, targeted and genome-scale molecular data is analyzed with histologic and clinical phenotypic data. NS is unique in that genomic data derived from kidney tissue and urine allows the study of cells and fluids directly impacted by this syndrome. A mechanistic understanding of NS allows us to identify functionally homogenous subtypes of NS, more accurately predict outcomes, and illuminate targets for precision intervention.