Skip to main content
. 2014 Nov 18;107(10):2325–2336. doi: 10.1016/j.bpj.2014.10.013

Figure 1.

Figure 1

Topology of the EpoR. (A) Diagram of the EpoR. The extracellular region, TMD and JM region, and cytoplasmic region are shown in blue, gray, and green, respectively. The membrane is shown as a brown box. The TMD contains residues L216–L247. (B) Topology of the hEpoR construct used in this study. The hEpoR sequence was obtained from the UniProt Knowledgebase (http://www.uniprot.org; accession number P19235). Sequence numbering does not include the N-terminal 25-residue signal peptide. (C) Sequence alignment of hEpoR and mEpoR. The TMD is highlighted with solid lines and the JM region is highlighted with blue and dashed lines. The different amino acids are indicated with triangles. The conserved hydrophobic residues in the JM region are indicated with black circles. To see this figure in color, go online.