Figure 5.

Theoretical predictions of transmembrane protein self-diffusion coefficients. (Top) Transmembrane protein diffusion coefficient versus the interleaflet friction coefficient b₁₂ = γ₁₂η_mh. Other parameters are chosen to mimic lipid diffusion based on literature estimates (5,15): η = 0.001 Pa s, η_m = 0.08 Pa s, h = 2.5 nm, a = 2 nm, $\ell$₁ = δ₁ = η_mh/η, and $\ell$₂ = δ₂ = 2a. (Bottom) Transmembrane protein diffusion coefficient versus the Brinkman screening length $\ell$₂ with b₁₂ = 2 × 10⁶ Pa s cm⁻¹. (Solid lines) Gel-supported dual-leaflet model (blue) and the solid-supported dual-leaflet model of Hill and Wang (30) (red), both with no slip (δ_N → 0) between the tracer and leaflets. (Dashed lines) Solid-supported dual-leaflet model with perfect slip (δ_N → ∞) between the tracer and leaflets. To see this figure in color, go online.