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. Author manuscript; available in PMC: 2014 Nov 24.
Published in final edited form as: Cochrane Database Syst Rev. 2010 Aug 4;(8):CD007701. doi: 10.1002/14651858.CD007701.pub2
Methods RCT, 2-arm trial.
Participants Setting: 40 women, setting not clear.
Inclusion criteria: women with gestational age 40-42 weeks, singleton, cephalic presentation, intact membranes, Bishop score < 6, reassuring FHR and < 3 contractions in 10 minutes
Interventions Intervention group: 100 mg oral misoprostol, dose repeated every 24 hrs with max of 3 doses. 2 hrs continual fetal monitoring after each dose
Comparison group: placebo, with same regime and monitoring as the intervention group
Outcomes Chorioamnionitis, meconium aspiration, uterine hyperstimulation, mean time to active labour
Notes Study reported in brief abstract.
Risk of bias
Item Authors’ judgement Description
Adequate sequence generation? Unclear Described as “randomized”.
Allocation concealment? Unclear Placebo controlled, no information on randomisation procedure
Blinding?
Women
Yes Described as double-blind, placebo controlled study.
Blinding?
Clinical staff
Yes
Blinding?
Outcome assessor
Unclear Not described.
Incomplete outcome data addressed?
All outcomes
Unclear All women appeared to have been followed up, but little information