Methods	RCT 2-arm parallel group design.
Participants	84 women attending a USA hospital between 199 to 2001. Inclusion criteria: singleton, cephalic presentation, intact membranes, Bishop score of 6 or less, reactive NST Exclusion criteria: ruptured membranes, Bishop score > 6, contraindication to induction, > 3 contractions in 10 min, uterine scar
Interventions	Intervention group: vaginal misoprostol 25 mcg. Comparison group: intracervical PGE2 gel (dinoprostone) 0.5 mg Women in both groups were randomised after a reactive NST. After drug administration women had continuous fetal heart rate monitoring for 3hrs with discharge home if clinically stable. Women were asked to return the next day (after 18 hrs) for oxytocin induction if labour was not established
Outcomes	Vaginal delivery within 24 or 48 hrs, uterine hyperstimulation, CS, oxytocin required, Apgar score < 7 at 5 min, NICU admission
Notes
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Yes	Random number table.
Allocation concealment?	Yes	Opaque sequentially numbered envelopes (not stated whether sealed)
Blinding? Women	No	Blinding women would be feasible but the study was not blinded
Blinding? Clinical staff	No
Blinding? Outcome assessor	No
Incomplete outcome data addressed? All outcomes	Yes	84 women were randomised (42 in each group), 2 women were lost to follow up in the misoprostol group but were included in the denominators
Free of other bias?	Yes	None apparent.