Comparison 1.
Intravaginal PGE2 gel versus placebo or expectant management
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Additional induction agents required | 2 | 150 | Risk Ratio (M-H, Fixed, 95% CI) | 0.52 [0.27, 0.99] |
| 2 Serious neonatal morbidity or death | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 3 Serious maternal morbidity or death | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 4 Vaginal delivery not achieved in 24/48 hrs | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 5 Uterine hyperstimulation (FHR changes unclear) | 4 | 244 | Risk Ratio (M-H, Fixed, 95% CI) | 3.76 [0.64, 22.24] |
| 6 Uterine hyperstimulation (without FHR changes) | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 7 Caesarean section | 4 | 288 | Risk Ratio (M-H, Fixed, 95% CI) | 0.80 [0.49, 1.31] |
| 8 Assisted (instrumental) vaginal delivery | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 9 Oxytocin augmentation | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 10 Epidural | 1 | 100 | Risk Ratio (M-H, Fixed, 95% CI) | 0.83 [0.62, 1.12] |
| 11 Maternal death | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 12 Uterine rupture | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 13 Serious maternal complication | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 14 Chorioamnionitis | 2 | 180 | Risk Ratio (M-H, Fixed, 95% CI) | 0.37 [0.15, 0.90] |
| 15 Endometritis | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 16 Maternal antibiotics | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 17 Perinatal death | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 18 Apgar score < 7 at 5 minutes | 2 | 180 | Risk Ratio (M-H, Fixed, 95% CI) | 0.45 [0.07, 2.93] |
| 19 NICU admission | 3 | 230 | Risk Ratio (M-H, Fixed, 95% CI) | 0.32 [0.10, 1.03] |
| 20 Neonatal antibiotics | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 21 Neonatal infection | 0 | 0 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 22 Interval from intervention to delivery | 0 | 0 | Mean Difference (IV, Fixed, 95% CI) | Not estimable |
| 23 Cervix unchanged at follow up | 1 | 36 | Risk Ratio (M-H, Fixed, 95% CI) | 0.13 [0.03, 0.47] |
| 24 “Spontaneous labour” within 48 hours | 1 | 58 | Risk Ratio (M-H, Fixed, 95% CI) | 6.43 [2.12, 19.48] |
| 25 Admitted to hospital for labour | 1 | 100 | Risk Ratio (M-H, Fixed, 95% CI) | 2.7 [1.47, 4.97] |
| 26 Gestational age at delivery (weeks) | 1 | 100 | Mean Difference (IV, Fixed, 95% CI) | −0.60 [−0.99, −0.21] |
| 27 Gestational age on admission (days) | 1 | 80 | Mean Difference (IV, Fixed, 95% CI) | −2.0 [−4.17, 0.17] |