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. Author manuscript; available in PMC: 2014 Nov 24.
Published in final edited form as: Future Microbiol. 2012 Mar;7(3):347–367. doi: 10.2217/fmb.12.4

Figure 2. Strategies employed to enhance anti-tumor activity of NDV via genetic engineering.

Figure 2

Several approaches have been demonstrated to improve anti-tumor activity of NDV. Those include enhancement of intrinsic cytolytic properties of NDV via 1) increased fusogenicity; 2) inhibition of innate immune responses; and 3) expression of proapoptotic proteins; as well as enhancement of immune-mediated anti-tumor effects via 1) expression of tumor-associated antigens (TAA), leading to activation and expansion of tumor-specific lymphocytes; 2) expression of tumor-directed antibodies with activation of antibody-dependent cell-mediated cytotoxicity (ADCC); and 3) expression of immunostimulatory cytokines, leading to activation and recruitment of lymphocytes and dendritic cells (DC).