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. 2014 Sep 16;1(9):659–669. doi: 10.1002/acn3.94

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© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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B-cell depletion with anti-CD20 antibody reduces the area of microglial activation in DTH-EAE rat model. (A) In situ hybridization of coronal brain sections with [¹²⁵I]DPA-713. White arrows indicate the location of the lesion, black arrows demonstrate the binding in the ventricles caused by binding to ependymal cells and the Choroid Plexus. (B) [¹²⁵I]DPA-713 binding in DTH-EAE lesions (Control, n = 5, anti-CD20 n = 6), *P = 0.012. (C) Immunohistochemistry showing the area of OX-6+ (MHCII, brown staining) staining surrounding a typical lesion in both a control animal and anti-CD20-treated animal. Nuclei visualized using cresyl violet (blue). (D) Volumetry of lesions calculated by measuring the area of OX-6 staining throughout the lesion (Control, n = 9; anti-CD20, n = 10), ***P < 0.001. EAE, experimental allergic encephalomyelitis.