Table 2.
Group MRSI data from control subjects, veterans with explosive blast mTBI and PTSD with no blast
| Left | Right | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 1 | 2 | 3 | 4 | 5 | 6 | |
| NAA/Cr | ||||||||||||
| Blast TBI (N = 25) | ||||||||||||
| Avg | 1.50 | 1.31 | 1.29 | 1.27 | 1.15 | 1.18 | 1.46 | 1.30 | 1.29 | 1.20 | 1.06 | 1.05 |
| SD | 0.17 | 0.11 | 0.16 | 0.20 | 0.15 | 0.19 | 0.16 | 0.08 | 0.10 | 0.12 | 0.13 | 0.18 |
| P value | NS | NS | NS | NS | NS | NS | NS | NS | 3.97E-02 | 3.52E-03 | 2.74E-02 | 5.59E-04 |
| PTSD (N = 12) | ||||||||||||
| Avg | 1.48 | 1.25 | 1.25 | 1.21 | 1.16 | 1.20 | 1.47 | 1.28 | 1.31 | 1.26 | 1.10 | 1.13 |
| SD | 0.26 | 0.13 | 0.13 | 0.15 | 0.15 | 0.30 | 0.18 | 0.08 | 0.14 | 0.17 | 0.17 | 0.18 |
| P value | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | NS | 3.97E-02 |
| Control (N = 20) | ||||||||||||
| Avg | 1.47 | 1.32 | 1.33 | 1.32 | 1.21 | 1.21 | 1.46 | 1.34 | 1.37 | 1.31 | 1.17 | 1.29 |
| SD | 0.15 | 0.10 | 0.12 | 0.17 | 0.17 | 0.17 | 0.16 | 0.10 | 0.12 | 0.11 | 0.16 | 0.22 |
| NAA/Ch | ||||||||||||
| Blast TBI (N = 25) | ||||||||||||
| Avg | 1.69 | 1.36 | 1.24 | 1.12 | 0.95 | 0.86 | 1.68 | 1.37 | 1.26 | 1.11 | 0.92 | 0.81 |
| SD | 0.23 | 0.14 | 0.15 | 0.16 | 0.15 | 0.18 | 0.20 | 0.14 | 0.16 | 0.17 | 0.14 | 0.19 |
| P value | NS | NS | NS | NS | 1.04E-02 | 1.25E-02 | NS | 2.62E-02 | 1.03E-02 | 2.05E-02 | 3.72E-03 | 1.78E-05 |
| PTSD (N = 12) | ||||||||||||
| Avg | 1.60 | 1.27 | 1.21 | 1.13 | 1.07 | 0.95 | 1.63 | 1.35 | 1.24 | 1.10 | 1.00 | 0.91 |
| SD | 0.26 | 0.13 | 0.16 | 0.16 | 0.21 | 0.26 | 0.17 | 0.14 | 0.18 | 0.19 | 0.17 | 0.20 |
| P value | NS | 3.92E-03 | 3.84E-02 | NS | NS | NS | 3.80E-02 | 3.19E-02 | 3.85E-02 | NS | NS | 3.00E-02 |
| Control (N = 20) | ||||||||||||
| Avg | 1.71 | 1.43 | 1.33 | 1.22 | 1.08 | 0.99 | 1.77 | 1.46 | 1.38 | 1.22 | 1.05 | 1.07 |
| SD | 0.18 | 0.14 | 0.12 | 0.20 | 0.16 | 0.16 | 0.15 | 0.11 | 0.12 | 0.13 | 0.13 | 0.16 |
The numbers in bold black have a P < 0.05 two-tailed t-test, false discovery rate (FDR) P > 0.05. Those in italics P < 0.05 two-tailed t-test, FDR P < 0.05. The P values shown are for comparisons of controls versus Blast TBI or PTSD. The FDR test takes into account the comparison of a large number of measures and is more effective than an ANOVA analysis. There are no significant differences between the PTSD-only group and the blast TBI group measures compared against each other. MRSI, magnetic resonance spectroscopic imaging; mTBI, mild traumatic brain injury; PTSD, posttraumatic stress disorder.