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. 2014 Oct 9;1(10):739–754. doi: 10.1002/acn3.127

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© 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of rcHIP/PAP on ibotenate-induced cell death determined by cleaved caspase-3 immunohistochemistry (A), Fluoro-Jade B staining (B), and AIF immunohistochemistry (C). Pups were injected with ibotenate on P5 and sacrificed 1 or 5 days later. PBS or rcHIP/PAP (0.75 μg) were injected i.p. immediately after ibotenate. Values represent mean density of positive cells ± SEM. Asterisks indicate statistically significant difference from controls (black bars); *P < 0.05, **P < 0.01, ANOVA with Dunnett’s multiple comparison test. HIP/PAP, hepatocarcinoma intestine pancreas protein/pancreatitis-associated protein; AIF, apoptosis-inducing factor.