Table 5.

Mean EDSS and KPS scores over time in asymptomatic and symptomatic PML patients

	Asymptomatic PML patients	Symptomatic PML patients	P value
EDSS score
Pre-PML	3.2 (n = 21)	3.7 (n = 179)	0.336
At diagnosis	4.1 (n = 11)	5.4 (n = 193)	0.038
At 6 months	4.9 (n = 11)	6.6 (n = 87)	0.007
At 12 months	5.1 (n = 6)	6.5 (n = 59)	0.169
KPS score
Pre-PML	84.0 (n = 10)	81.1 (n = 97)	0.475
At diagnosis	70.0 (n = 11)	53.8 (n = 122)	0.008
At 6 months	71.5 (n = 10)	47.1 (n = 108)	<0.001
At 12 months	56.0 (n = 5)	46.6 (n = 67)	0.178

P value from Mann–Whitney–Wilcoxon test. EDSS, Expanded Disability Status Scale; KPS, Karnofsky Performance Scale; PML, progressive multifocal leukoencephalopathy.

Bold text indicates statistical significance.