Table 3.
Max SUV of regions of interest
| Region of Interest | Max SUV (SE) baseline | 95% CI baseline | Max SUV (SE) follow-up | 95% CI follow-up | P-value baseline vs. follow-up | Avg. % change baseline vs. follow-up | 95% CI |
|---|---|---|---|---|---|---|---|
| Gray matter | |||||||
| Right caudate head | 9.85 (1.08) | 7.4–12.3 | 8.23 (1.10) | 5.8–10.7 | 0.017 | −17.0 | −0.32 to −0.03 |
| Left caudate head | 9.54 (0.83) | 7.7–11.4 | 8.05 (1.10) | 5.6–10.5 | 0.021 | −17.0 | −0.30 to −0.05 |
| Right thalamus | 10.26 (0.99) | 8.4–12.1 | 8.10 (0.99) | 5.9–10.3 | 0.014 | −21.0 | −0.36 to −0.06 |
| Left thalamus | 10.34 (0.83) | 8.5–12.2 | 8.24 (0.95) | 6.1–10.4 | 0.012 | −20.0 | −0.34 to −0.06 |
| Right frontal cortex | 12.05 (0.96) | 9.9–14.2 | 9.07 (1.01) | 6.8–11.4 | 0.004 | −24.0 | −0.38 to −0.11 |
| Left frontal cortex | 11.35 (0.97) | 9.1–13.5 | 8.72 (0.96) | 6.5–10.9 | 0.004 | −23.0 | −0.35 to −0.11 |
| Right parietal cortex | 11.24 (0.92) | 9.2–13.3 | 8.92 (0.99) | 6.7–11.2 | 0.014 | −20.0 | −0.36 to −0.04 |
| Left parietal cortex | 10.82 (1.03) | 8.5–13.1 | 8.55 (1.00) | 6.3–10.8 | 0.015 | −20.0 | −0.35 to −0.05 |
| Right cerebellum | 9.80 (0.84) | 7.9–11.7 | 8.02 (0.80) | 6.2–9.8 | 0.020 | −17.0 | −0.31 to −0.03 |
| Left cerebellum | 9.75 (0.85) | 7.8–11.7 | 7.86 (0.76) | 6.1–9.6 | 0.021 | −18.0 | −0.32 to −0.04 |
| Post cingulate gyrus | 11.50 (1.06) | 9.1–13.9 | 9.11 (1.04) | 6.7–11.5 | 0.006 | −20.0 | −0.34 to −0.07 |
| Right olfactory gyrus | 9.92 (0.67) | 8.4–11.4 | 7.75 (0.70) | 6.2–9.3 | 0.001 | −22.0 | −0.33 to −0.11 |
| Left olfactory gyrus | 9.93 (0.67) | 8.4–11.4 | 7.77 (0.76) | 6.1–9.5 | 0.002 | −22.0 | −0.34 to −0.07 |
| White matter | |||||||
| Right paraventricular WM | 5.53 (0.90) | 4.9–6.2 | 4.80 (1.00) | 4.1–5.5 | 0.007 | −13.0 | −0.22 to −0.05 |
| Left paraventricular WM | 5.42 (1.05) | 4.6–6.2 | 4.69 (1.02) | 4.0–5.4 | 0.120 (n.s.) | −11.0 | −0.29 to −0.08 |
| Corpus callosum | 4.97 (1.15) | 4.2–5.8 | 4.15 (1.20) | 3.3–5.8 | 0.004 | −17.0 | −0.26 to −0.07 |
| Right subcortical WM | 4.93 (2.92) | 2.8–7.0 | 4.53 (1.43) | 3.5–5.5 | 0.550 (n.s.) | 0.0 | −0.19 to +0.18 |
| Left subcortical WM | 5.08 (3.33) | 2.7–7.5 | 4.16 (1.45) | 3.1–5.2 | 0.212 (n.s.) | −10.0 | −0.26 to +0.05 |
| Posterior corpus callosum | 7.56 (5.80) | 3.4–11.7 | 6.04 (4.17) | 3.1–9.0 | 0.059 (n.s.) | −13.0 | −0.30 to +0.11 |
| Cerebellar WM | 8.87 (5.31) | 5.1–12.7 | 7.36 (3.68) | 4.7–10.0 | 0.129 (n.s.) | −9.0 | −0.29 to −0.08 |
| Germinal zone | |||||||
| Right hippocampus | 6.90 (1.55) | 5.8–8.0 | 6.31 (2.08) | 4.8–7.8 | 0.150 (n.s.) | −9.0 | −0.21 to +0.03 |
| Left hippocampus | 7.00 (1.91) | 5.6–8.4 | 6.24 (1.93) | 4.9–7.6 | 0.106 (n.s.) | −9.0 | −0.23 to +0.04 |
| Right SVZ | 5.35 (1.45) | 4.3–6.4 | 4.62 (1.32) | 3.7–5.6 | 0.009 | −13.0 | −0.23 to −0.03 |
| Left SVZ | 4.60 (1.21) | 3.7–5.5 | 4.23 (1.43) | 3.2–5.3 | 0.121 (n.s.) | −9.0 | −0.20 to +0.02 |
| All gray matter ROI | 10.49 (0.23) | 10.00–10.98 | 8.34 (0.25) | 7.84–8.84 | 0.0001 | −20.0 | −0.14 to −0.26 |
| All white matter ROI | 6.05 (0.43) | 5.19–6.91 | 5.10 (0.30) | 4.51–5.70 | 0.0001 | −10.0 | −0.05 to −0.16 |
| Germinal zones | 5.96 (0.29) | 5.38–6.54 | 5.33 (0.30) | 4.73–5.93 | 0.0002 | −10.0 | −0.05 to −0.15 |
SUV, standardized uptake value; WM, white matter; SVZ, subventricular zone; ROI, regions of interest; SE, standard error; CI, confidence interval; n.s., not significant.