Table 4.
Mean SUV of regions of interest
| Region of interest | Mean SUV (SE) baseline | 95% CI baseline | Mean SUV (SE) follow-up | 95% CI follow-up | P-value baseline vs. follow-up | Avg. % change baseline vs. follow-up | 95% CI |
|---|---|---|---|---|---|---|---|
| Gray matter | |||||||
| Right caudate head | 8.35 (0.74) | 6.7–10.0 | 6.78 (2.60) | 4.9–8.6 | 0.008 | −20.0 | −0.33 to −0.07 |
| Left caudate head | 8.38 (0.70) | 6.8–10.0 | 6.77 (2.57) | 4.9–8.6 | 0.004 | −20.0 | −0.32 to −0.08 |
| Right thalamus | 9.02 (0.81) | 7.4–10.6 | 7.00 (2.57) | 5.2–8.8 | 0.010 | −22.0 | −0.36 to −0.08 |
| Left thalamus | 9.07 (0.71) | 7.5–10.7 | 7.19 (2.50) | 5.4–9.0 | 0.012 | −20.0 | −0.33 to −0.07 |
| Right frontal cortex | 10.33 (0.78) | 8.6–12.1 | 7.55 (2.52) | 5.7–9.4 | 0.004 | −26.0 | −0.40 to −0.10 |
| Left frontal cortex | 9.94 (0.80) | 7.8–11.4 | 7.41 (2.50) | 5.6–9.2 | 0.004 | −23.0 | −0.36 to −0.07 |
| Right parietal cortex | 9.61 (0.80) | 7.8–11.4 | 7.60 (2.57) | 5.8–9.4 | 0.014 | −20.0 | −0.35 to −0.05 |
| Left parietal cortex | 9.27 (0.87) | 7.3–11.2 | 7.22 (2.46) | 5.4–9.0 | 0.008 | −21.0 | −0.34 to −0.08 |
| Right cerebellum | 8.35 (0.61) | 7.0–9.7 | 6.81 (2.03) | 5.4–8.3 | 0.016 | −18.0 | −0.32 to −0.04 |
| Left cerebellum | 8.40 (0.67) | 6.9–9.9 | 6.80 (1.92) | 5.4–78.2 | 0.010 | −18.0 | −0.30 to −0.06 |
| Post cingulate gyrus | 10.19 (0.89) | 8.2–12.2 | 8.14 (2.65) | 6.2–10.0 | 0.008 | −19.0 | −0.33 to −0.06 |
| Right olfactory gyrus | 8.94 (0.62) | 7.5–10.3 | 6.82 (1.86) | 5.5–8.2 | 0.001 | −23.0 | −0.33 to −0.14 |
| Left olfactory gyrus | 9.02 (0.63) | 7.6–10.4 | 6.88 (1.96) | 5.5–8.3 | 0.001 | −23.0 | −0.33 to −0.14 |
| White matter | |||||||
| Right paraventricular WM | 4.17 (0.22) | 3.7–4.7 | 3.63 (0.50) | 3.3–4.0 | 0.018 | −12.0 | −0.22 to −0.008 |
| Left paraventricular WM | 3.69 (0.24) | 3.2–4.2 | 3.26 (0.60) | 2.8–3.7 | 0.063 (n.s.) | −10.0 | –0.23 to +0.04 |
| Corpus callosum (genu) | 3.83 (0.18) | 3.4–4.2 | 3.29 (0.82) | 2.7–4.2 | 0.018 | −14.0 | –0.26 to −0.04 |
| Right subcortical WM | 3.71 (0.40) | 2.8–4.6 | 3.38 (.078) | 2.8–3.9 | 0.294 (n.s.) | −6.0 | –0.20 to +0.09 |
| Left subcortical WM | 3.69 (0.42) | 2.7–4.6 | 3.31 (0.75) | 2.8–3.8 | 0.215 (n.s.) | −7.0 | –0.20 to +0.06 |
| Corpus callosum (splenium) | 4.62 (0.18) | 3.0–6.3 | 4.01 (1.74) | 2.8–5.3 | 0.098 (n.s.) | −9.0 | –0.21 to +0.04 |
| Cerebellar WM | 6.00 (0.51) | 4.9–7.1 | 5.32 (1.42) | 4.3–6.3 | 0.178 (n.s.) | −9.0 | –0.27 to +0.09 |
| Germinal Zone | |||||||
| Right hippocampus | 6.40 (0.49) | 5.3–7.5 | 5.71 (1.87) | 4.4–7.0 | 0.081 (n.s.) | −11.0 | –0.23 to +0.01 |
| Left hippocampus | 6.43 (0.56) | 5.2–7.7 | 5.77 (1.79) | 4.5–7.1 | 0.065 (n.s.) | −9.0 | –0.21 to +0.02 |
| Right SVZ | 4.53 (0.38) | 3.7–5.4 | 3.94 1.01) | 3.2–4.7 | 0.036 | −12.0 | –0.24 to +0.002 |
| Left SVZ | 4.04 (0.34) | 3.3–4.8 | 3.57 (1.08) | 2.8–4.3 | 0.043 | −11.0 | –0.23 to +0.004 |
| All gray matter ROI | 9.12 (0.20) | 8.72–9.52 | 7.04 (0.19) | 6.7–7.41 | 0.00003 | −22.0 | −0.25 to −0.19 |
| All white matter ROI | 4.24 (0.18) | 3.89–4.60 | 3.74 (0.14) | 3.5–4.0 | 0.00001 | −9.0 | −0.14 to −0.05 |
| Germinal zones | 5.35 (0.28) | 4.79–5.91 | 4.75 (0.28) | 4.19–5.31 | 0.00007 | −11.0 | −0.16 to −0.06 |
SUV, standardized uptake value; WM, white matter; SVZ, subventricular zone; ROI, regions of interest; SE, standard error; CI, confidence interval; n.s., not significant.